Plenhyage XL Strong Polynucleotide Skin Regeneration Treatment
Plenhyage XL Strong is an advanced injectable regenerative treatment containing 2.5% high-molecular-weight polymerised polynucleotides (25 mg/ml). It is developed by Bioformula and uses highly purified salmon-derived DNA to support the skin’s natural regenerative processes and improve overall tissue quality. It is not a conventional hyaluronic acid dermal filler. Its purpose is to support biological skin regeneration, hydration, fibroblast activity and tissue remodelling rather than create artificial volume.
Key Benefits
- Supports biological skin regeneration and tissue revitalisation
- Helps improve skin elasticity and firmness
- Provides intensive hydration to support healthier-looking skin
- Supports fibroblast activity, creating favourable conditions for tissue regeneration
- Helps promote cellular turnover and skin remodelling
- Supports improvements in skin density and overall skin quality
- Helps address signs of ageing and photoageing
- Provides antioxidant activity to help protect against free-radical damage
- Suitable for skin affected by reduced elasticity, dehydration and tissue quality concerns
- Biocompatible and resorbable polynucleotide formulation
Suitable Treatment Areas
- Face
- Neck
- Décolleté
- Body
How Plenhyage XL Strong Works
It contains high-molecular-weight polymerised polynucleotides, these molecules have hydrating and antioxidant properties. They are made to create an environment for fibroblast activity.
By supporting the skin’s natural regenerative processes, Plenhyage XL Strong helps improve hydration, elasticity and tissue quality while supporting cellular turnover and dermal remodelling.
The higher 25 mg/ml polynucleotide concentration makes Plenhyage XL Strong the more concentrated formulation within the Plenhyage range, compared with Plenhyage Medium at 20 mg/ml.
Product Specifications
| Specification | Details |
|---|---|
| Product Name | Plenhyage XL Strong |
| Manufacturer | Bioformula, Italy |
| Active Ingredient | High-molecular-weight polymerised polynucleotides |
| Concentration | 2.5% / 25 mg/ml |
| Source | Highly purified salmon-derived DNA |
| Volume | 2 ml |
| Presentation | 1 pre-filled glass syringe |
| Needles | 2 disposable needles |
| Recommended Areas | Face, neck, décolleté and body |
| Product Type | Injectable regenerative medical device |
| Regulatory Status | Class III Medical Device, CE 0373 |
| Intended Use | Professional medical use only |
Plenhyage XL Strong is a Class III CE 0373 medical device it is only for professional medical use. The product administration must only be undertaken by an appropriately qualified medical professional.



